2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. EGFR Antibody-Drug Conjugates (ADCs)
  4. Trastuzumab emtansine (solution)

Trastuzumab emtansine (solution)  (Synonyms: Ado-Trastuzumab emtansine (solution) ; PRO132365 (solution) ; T-DM 1 (solution))

Cat. No.: HY-P9921A Purity: 99.01%
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COA
Handling Instructions Technical Support

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer.

For research use only. We do not sell to patients.

Trastuzumab emtansine (solution) Chemical Structure

Trastuzumab emtansine (solution) Chemical Structure

CAS No. : 1018448-65-1

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2 Publications Citing Use of MCE Trastuzumab emtansine (solution)

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Description

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].

In Vitro

Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trastuzumab emtansine (solution) Related Antibodies
In Vivo

Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Trastuzumab emtansine (solution)]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.01%

SDS (251 KB)

COA (231 KB) SEC-HPLC (141 KB)

Handling Instructions (2659 KB)
References
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Trastuzumab emtansine (solution) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trastuzumab emtansine (solution)1018448-65-1Ado-Trastuzumab emtansine (solution) PRO132365 (solution) T-DM 1 (solution)EGFRAntibody-Drug Conjugates (ADCs)Epidermal growth factor receptorErbB-1HER1Antibody-Drug ConjugatesAntibody-Drug ConjugateADCDM1HER2Inhibitorinhibitorinhibit

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