2. PROTAC
  3. PROTACs
  4. TrimTAC1

TrimTAC1 is a PROTAC degrader that selectively targets the degradation of the multimeric protein Nucleoporin. TrimTAC1 is composed of PROTAC target protein ligand (red part) (+)-JQ-1 (HY-13030), E3 ligase ligand (blue part) Acepromazine-OTs (HY-169356) and PROTAC linker (black part) tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate (HY-W088456). Among them, its E3 ligase ligand + linker can form Acepromazine-1-Piperazinepropanamine (HY-169357).

For research use only. We do not sell to patients.

TrimTAC1 Chemical Structure

TrimTAC1 Chemical Structure

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TrimTAC1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

TrimTAC1 is a PROTAC degrader that selectively targets the degradation of the multimeric protein Nucleoporin[1]. TrimTAC1 is composed of PROTAC target protein ligand (red part) (+)-JQ-1 (HY-13030), E3 ligase ligand (blue part) Acepromazine-OTs (HY-169356) and PROTAC linker (black part) tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate (HY-W088456). Among them, its E3 ligase ligand + linker can form Acepromazine-1-Piperazinepropanamine (HY-169357).

IC50 & Target

Nucleoporin[1]
Molecular Weight

807.47

Formula

C43H47ClN8O2S2
SMILES

O=C(NCCCN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(C(C)=O)C=C4)CC1)C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TrimTAC1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrimTAC1TrimTAC 1TrimTAC-1PROTACsInhibitorinhibitorinhibit

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