2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. Triptonodiol

Triptonodiol can be isolated from Trypterygium wilfordii. Triptonodiol has anti-inflammatory and anti-cancer activity. Triptonodiol inhibits the biological activity of GSK.

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Triptonodiol Chemical Structure

Triptonodiol Chemical Structure

CAS No. : 117456-87-8

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Based on 1 publication(s) in Google Scholar

Triptonodiol Related Antibodies

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Description

Triptonodiol can be isolated from Trypterygium wilfordii. Triptonodiol has anti-inflammatory and anti-cancer activity. Triptonodiol inhibits the biological activity of GSK[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
21.59 μM
Compound: 3
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 27133593]
Bcap37 IC50
> 100 μM
Compound: 3
Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay
Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay
[PMID: 27133593]
Hep 3B2 IC50
28.69 μM
Compound: 3
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
[PMID: 27133593]
HepG2 IC50
21.89 μM
Compound: 3
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 27133593]
MCF7 IC50
23.23 μM
Compound: 3
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 27133593]
U-251 IC50
> 100 μM
Compound: 3
Cytotoxicity against human U251 cells after 48 hrs by MTT assay
Cytotoxicity against human U251 cells after 48 hrs by MTT assay
[PMID: 27133593]
Molecular Weight

346.46

Formula

C21H30O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@](C)(CO)[C@]2([H])CCC3=C(C(O)=CC(C(C)C)=C3OC)[C@@]2(C)CC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Triptonodiol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triptonodiol117456-87-8GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Trypterygium wilfordiicancerinflammationGSKNSCLCInhibitorinhibitorinhibit

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