2. Neuronal Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. Trk Receptor Apoptosis
  4. TRK-IN-23

TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells.

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TRK-IN-23 Chemical Structure

TRK-IN-23 Chemical Structure

CAS No. : 2924344-29-4

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Based on 1 publication(s) in Google Scholar

TRK-IN-23 Related Antibodies

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TrkA TrkB TrkC Trk

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Description

TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].

IC50 & Target[1]

TrkA

0.5 nM (IC50)

TrkC

9 nM (IC50)

TRKAG595R

14 nM (IC50)

TRKAF589L

4.4 nM (IC50)

TRKAG667C

4.8 nM (IC50)

Molecular Weight

364.37

Formula

C20H17FN4O2
CAS No.
SMILES

COC1=CC=C(C=C1CNC2=CC3=C(NC(/C3=C\C4=CN=CN4)=O)C=C2)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRK-IN-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-IN-232924344-29-4Trk ReceptorApoptosisTropomyosin related kinase receptor TRKATRKCTRKAG595RTRKAF589LTRKAG667Corally activeapoptosisInhibitorinhibitorinhibit

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