TRK-IN-29

Cat. No.: HY-161819: FAQs
Data Sheet Handling Instructions

Molarity Calculator

TRK-IN-29 (Compound B31) is a second-generation TRK inhibitor (IC₅₀: 9 nM, 0.6 nM, 18 nM, 5 nM, 6 nM for TRKA^G595R, TRKA^F589L, TRKA^G667C, TRKA and TRKC respectively). TRK-IN-29 inhibits the phosphorylation of TRKA. TRK-IN-29 has good antiproliferative activities against NTRK fusion positive cells. TRK-IN-29 has exellent plasma stability and moderate pharmacokinetic properties.

For research use only. We do not sell to patients.

TRK-IN-29 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Trk Receptor Isoform Specific Products:

View All Isoforms

TrkA TrkB TrkC Trk

Biological Activity
Purity & Documentation
References
Customer Review

Description	TRK-IN-29 (Compound B31) is a second-generation TRK inhibitor (IC₅₀: 9 nM, 0.6 nM, 18 nM, 5 nM, 6 nM for TRKA^G595R, TRKA^F589L, TRKA^G667C, TRKA and TRKC respectively). TRK-IN-29 inhibits the phosphorylation of TRKA. TRK-IN-29 has good antiproliferative activities against NTRK fusion positive cells. TRK-IN-29 has exellent plasma stability and moderate pharmacokinetic properties^[1].
In Vitro	TRK-IN-29 shows strong antiproliferative activities against Km-12, Ba/F3-TRKA^G595R, and Ba/F3-TRKA^G667C cell lines with IC₅₀ values of 0.3, 4.7, and 9.9 nM, respectively^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. TRK-IN-29 Related Antibodies
Molecular Weight	402.37
Formula	C₁₉H₁₇F₃N₆O
SMILES	C[C@H](C1=CC(F)=CC=C1OCC(F)F)NC2=CC3=C(NN=C3N4N=CN=C4)C=C2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Qiaohua Qin, et al. Discovery of novel indazole derivatives as second-generation TRK inhibitors. European Journal of Medicinal Chemistry. Available online 1 July 2024, 116640, et al.

TRK-IN-29 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRK-IN-29Trk ReceptorTropomyosin related kinase receptorNTRKTRKKm-12TRK mutantInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #