2. Apoptosis
  3. Apoptosis
  4. TrxR inhibitor D9

TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo.

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TrxR inhibitor D9 Chemical Structure

TrxR inhibitor D9 Chemical Structure

CAS No. : 1527513-89-8

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TrxR inhibitor D9 Related Antibodies

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Description

TrxR inhibitor D9 is a potent and selective inhibitor of thioredoxin reductase (TrxR), with an EC50 of 2.8 nM. TrxR inhibitor D9 has the capability to inhibit tumor proliferation both in vitro and in vivo[1][2].

IC50 & Target

EC50: 2.8 nM (TrxR)[1]
In Vitro

TrxR inhibitor D9 (0.1-1 μM; 72 h) inhibits the cell proliferation with IC50s of 0.03 and 0.1 μM for MCF-7 and HT-29 cells, respectively[1].
TrxR inhibitor D9 (72 h) completely inhibits all cancer cells (A549, KB, MDA MB-231, HeLa, MCF-7 and HT-29) viability at the concentration of 0.60 μM, and the IC50s of all cancer cells could be as low as 0.55 μM, and dose not significantly affects normal cells viability[1].
TrxR inhibitor D9 (0.8 μM; 4 and 8 h) induces HT-29 cells necrosis/apoptosis[1].
TrxR inhibitor D9 (2-20 nM; 1-60 s) inhibits TrxR activity in a concentration-dependent manner[1].
TrxR inhibitor D9 (1-1000 nM) does not significantly inhibits the catalytic activity of glutathione reductase (GR) even when the concentration increases to more than 1000 nM[1].
TrxR inhibitor D9 (0.4 μM) could effectively avoid the ligand exchange with albumin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TrxR inhibitor D9 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7 and HT-29 cells
Concentration: 0.1, 0.5, 1 μM
Incubation Time: 72 hours
Result: Killed 70% MCF-7 cells and 50% HT-29 cells with the concentration as low as 0.1 μM.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0.8 μM
Incubation Time: 4 and 8 hours
Result: Led to more than 50% necrosis/apoptosis of cells compared to control after 4 h of treatment.
Induced all cells necrosis/apoptosis after 8 h of incubation.
In Vivo

TrxR inhibitor D9 (5 mg/kg; i.v. once every 2 d for 15 d) effectively inhibits the growth of tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (17-18 g) bearing a MCF-7 tumor[1]
Dosage: 5 mg/kg
Administration: I.v. once every 2 days for 15 days
Result: Inhibited tumor growth with IR (inhibition ratio) of 91.5% and was well tolerated.
Molecular Weight

596.43

Formula

C25H20AuOPS
CAS No.
SMILES

COC1=CC=C(C=C1)C#[C-][Au+][P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CS4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TrxR inhibitor D9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrxR inhibitor D91527513-89-8TrxR inhibitor D 9TrxR inhibitor D-9ApoptosisthioredoxinreductaseTrxRtumorcancerInhibitorinhibitorinhibit

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