Trypanothione synthetase-IN-4 

Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC₅₀ value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis^[1].

Trypanothione synthetase-IN-4 (15 μM) has activity against LiTryS for three substrates (ATP, GSH and Spd) with IC₅₀ values of 7.3 μM, 7.8 μM and 5.5 μM, respectively^[1].
Trypanothione synthetase-IN-4 (25 μM, 24 h) has antileishmanial activity with an EC₅₀ value of 0.4 μM in axenic amastigotes of L. infantum^[1].
Trypanothione synthetase-IN-4 (25 μM, 72 h) is active against intracellular amastigotes (EC₅₀=0.6 μM) and has a high selectivity index of 35.5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

573.63

C₂₉H₅₂INO₂

C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M. Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library, European Journal of Medicinal Chemistry (2022).