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  4. Trypanothione synthetase-IN-5

Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM.

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Trypanothione synthetase-IN-5 Chemical Structure

Trypanothione synthetase-IN-5 Chemical Structure

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Trypanothione synthetase-IN-5 Related Antibodies

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Description

Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM[1].

Molecular Weight

728.61

Formula

C35H39F2IN4O3
SMILES

O=C(N1CC[N+](C)(CC1)CCCC2=CC=CC=C2)N(CC3=CC=C(O3)C(NCCC4=CC=C(C=C4)F)=O)C5=CC=C(C=C5)F.[I-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trypanothione synthetase-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-5ParasiteLeishmania infantum TRInhibitorinhibitorinhibit

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