TS 155-2 (Synonyms: JBIR 100)

Cat. No.: HY-123095: FAQs
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TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis.

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TS 155-2 Chemical Structure

CAS No. : 1314486-37-7

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Description	TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis^[1]^[2].
In Vitro	TS 155-2 shows cytotoxic effect against HeLa cells (IC₅₀: 72.6 nM) at 48 h^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. TS 155-2 Related Antibodies
Molecular Weight	704.89
Formula	C₃₉H₆₀O₁₁
CAS No.	1314486-37-7
SMILES	O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\C)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(O)=O
Structure Classification	Antibiotics Macrolide Antibiotics
Initial Source	Microorganisms Streptomyces sp. IR027-SDHV6
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Ueda JY, et al. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo). 2010 Oct;63(10):627-9. [Content Brief] [2]. Molloy EM, et al. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorg Med Chem. 2016 Dec 15;24(24):6276-6290. [Content Brief]

TS 155-2 Related Classifications

Inflammation/Immunology Infection Endocrinology

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TS 155-21314486-37-7JBIR 100JBIR100JBIR-100AntibioticBacterialProton PumpantimicrobialV-ATPaseInhibitorinhibitorinhibit

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