2. Apoptosis
  3. Thymidylate Synthase Apoptosis
  4. TS-IN-6

TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54  μM, demonstrating significant antiproliferative activity. TS-IN-6 induces G1 phase cell cycle arrest and apoptosis (marked by substantial increases in both early and late apoptotic rates) and shows potential for research on cancers such as colon, breast, and liver cancers.

For research use only. We do not sell to patients.

TS-IN-6 Chemical Structure

TS-IN-6 Chemical Structure

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TS-IN-6 Related Antibodies

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Description

TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54  μM, demonstrating significant antiproliferative activity. TS-IN-6 induces G1 phase cell cycle arrest and apoptosis (marked by substantial increases in both early and late apoptotic rates) and shows potential for research on cancers such as colon, breast, and liver cancers[1].

IC50 & Target

IC50: 0.54 μM (TS)[1].
Molecular Weight

540.59

Formula

C29H22F2N6OS
SMILES

CC1=CC=CC=C1N2C(SCC3=CN(C4=CC=C(F)C=C4F)N=N3)=NN=C2COC5=CC=C6C=CC=CC6=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TS-IN-6 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TS-IN-6Thymidylate SynthaseApoptosisapoptosisHepG2MCF-7HEK-293HCT-116Colon cancerliver cancerbreast cancerInhibitorinhibitorinhibit

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