TTA-P1

Cat. No.: HY-10955: FAQs
Data Sheet Handling Instructions

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TTA-P1 is a potent state-independent compound inhibiting human T-type calcium channel. T-type calcium channels play a role in diverse physiological responses including neuronal burst firing, hormone secretion, and cell growth. TTA-P1 has the potential for the research of absence epilepsy.

For research use only. We do not sell to patients.

TTA-P1 Chemical Structure

CAS No. : 918333-06-9

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	14900 nM Compound: 30	Inhibition of human L-type Cav1.2 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assay Inhibition of human L-type Cav1.2 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assay	[PMID: 18817368]
HEK293	IC₅₀	25 nM Compound: 30	Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -80mV holding potential by whole cell patch clamp assay Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -80mV holding potential by whole cell patch clamp assay	[PMID: 18817368]
HEK293	IC₅₀	43 nM Compound: 30	Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assay Inhibition of human T-type Cav3.1 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assay	[PMID: 18817368]
HEK293	IC₅₀	44 nM Compound: 30	Inhibition of human T-type Cav3.3 expressed in HEK293 cells at -80mV holding potential by whole cell patch clamp assay Inhibition of human T-type Cav3.3 expressed in HEK293 cells at -80mV holding potential by whole cell patch clamp assay	[PMID: 18817368]
HEK293	IC₅₀	62 nM Compound: 30	Inhibition of human T-type Cav3.3 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assay Inhibition of human T-type Cav3.3 expressed in HEK293 cells at -100mV holding potential by whole cell patch clamp assay	[PMID: 18817368]

Molecular Weight

389.33

Formula

C₁₉H₂₇Cl₂FN₂O

CAS No.

918333-06-9

SMILES

ClC1=CC(C(NC[C@H]2CCN(CCC(C)(C)C)C[C@H]2F)=O)=CC(Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Uebele VN, Nuss CE, Fox SV, et al. Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochem Biophys. 2009;55(2):81-93. [Content Brief]

TTA-P1 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TTA-P1918333-06-9Calcium ChannelCa2+ channelsCa channelsstate-independentT-type calcium channelphysiologicalneuronal burst firinghormone secretioncell growthabsence epilepsyInhibitorinhibitorinhibit

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