Tubulin inhibitor 13 

Tubulin inhibitor 13 (E27) is a potent tubulin inhibitor with an IC₅₀ value of 16.1 μM for the tubulin polymerization inhibition. Tubulin inhibitor 13 inhibits migration and invasion of cancer cells, induces apoptosis and has anticancer activity^[1].

Tubulin inhibitor 13 (E27) (0-100 μM, 72 h) exhibits antitumor activity with the IC₅₀ values of 9.32 μM, 10.36μM and 7.81 μM against HepG2, A549 and HCT116, respectively, and shows cytotoxic effect on 293 T (human embryonic kidney cell) with an IC₅₀ value of 49.30 μM^[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) causes destruction, fragmentation and disintegration of microtubules, and significantly reduces cell migration in a dose-dependent manner in A549 cells^[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) induces apoptosis in a dose-dependent manner and blocks the cell cycle in the G2/M phase in A549 cells^[1].
Tubulin inhibitor 13 (E27) (5 or 10 μM, 24 h) promotes the expression of pro-apoptotic markers such as BAX, cleaved caspase-3 and cleaved caspase-9 and decreases the expression of the anti-apoptotic protein Bcl-2 in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

427.45

C₂₅H₂₁N₃O₄

2883436-66-4

COC1=CC=C2N=C(C=C(C2=C1)C(N(CC3=NC=CC=C3)C)=O)C4=CC=C5OCOC5=C4

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• [1]. Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486.  [Content Brief]