Tubulin inhibitor 7

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Tubulin inhibitor 7 (Compound 33c) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 7 inhibits tubulin polymerization with an IC₅₀ of 0.52 μM. Tubulin inhibitor 7 inhibits K562 cell growth with an IC₅₀ of 11 nM.

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Tubulin inhibitor 7 Chemical Structure

CAS No. : 1309925-41-4

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Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 0.52 μM (tubulin polymerization)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
5637	GI₅₀	0.0019 μM Compound: 33c	Antiproliferative activity against human 5637 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human 5637 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
A-375	GI₅₀	0.0027 μM Compound: 33c	Antiproliferative activity against human A375 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human A375 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
ASPC1	GI₅₀	> 10 μM Compound: 33c	Antiproliferative activity against human AsPC1 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human AsPC1 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
BT-549	IC₅₀	0.016 μM Compound: 33c	Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay Antiproliferative activity against human BT549 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
BXPC-3	GI₅₀	2.2494 μM Compound: 33c	Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human BxPC3 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
COLO 205	GI₅₀	4.2556 μM Compound: 33c	Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
COLO-678	GI₅₀	0.0623 μM Compound: 33c	Antiproliferative activity against human COLO-678 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human COLO-678 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
DLD-1	IC₅₀	0.016 μM Compound: 33c	Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay Antiproliferative activity against human DLD1 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
HT-1080	GI₅₀	0.0026 μM Compound: 33c	Antiproliferative activity against human HT1080 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human HT1080 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
HT-29	GI₅₀	5.6032 μM Compound: 33c	Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
IGROV-1	GI₅₀	0.0633 μM Compound: 33c	Antiproliferative activity against human IGROV1 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human IGROV1 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
K562	IC₅₀	0.011 μM Compound: 33c	Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis	[PMID: 21563750]
MDA-MB-436	GI₅₀	1.1309 μM Compound: 33c	Antiproliferative activity against human MDA-MB-436 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human MDA-MB-436 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
MG-63	GI₅₀	0.0018 μM Compound: 33c	Antiproliferative activity against human MG63 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human MG63 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
MIA PaCa-2	GI₅₀	8.4137 μM Compound: 33c	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
NCI-H460	IC₅₀	0.04 μM Compound: 33c	Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
PBMC	GI₅₀	> 10 μM Compound: 33c	Antiproliferative activity against human resting PBMC after 72 hrs by sulforhodamine staining method Antiproliferative activity against human resting PBMC after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
RD	GI₅₀	0.002 μM Compound: 33c	Antiproliferative activity against human RD cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human RD cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-MEL-28	GI₅₀	0.002 μM Compound: 33c	Antiproliferative activity against human SK-MEL-28 cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human SK-MEL-28 cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-N-AS	GI₅₀	0.0018 μM Compound: 33c	Antiproliferative activity against human SK-N-AS cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human SK-N-AS cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-N-SH	GI₅₀	0.0018 μM Compound: 33c	Antiproliferative activity against human SK-N-SH cells after 72 hrs by sulforhodamine staining method Antiproliferative activity against human SK-N-SH cells after 72 hrs by sulforhodamine staining method	[PMID: 21563750]
SK-OV-3	IC₅₀	0.024 μM Compound: 33c	Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay Antiproliferative activity against human SKOV3 cells after 48 hrs by alamar blue assay	[PMID: 21563750]
SW480	IC₅₀	0.029 μM Compound: 33c	Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay Antiproliferative activity against human SW480 cells after 48 hrs by alamar blue assay	[PMID: 21563750]

In Vitro

Tubulin inhibitor 7 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms^[1].
Tubulin inhibitor 7 shows excellent antiproliferative potencies with IC₅₀s of 40, 24, 16, 6, 29, and 16 nM for NCIH460, SKOV3, BT549, 451LU, SW480, and DLD-1 tumor cell lines, recpectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

358.35

Formula

C₂₁H₁₄N₂O₄

CAS No.

1309925-41-4

SMILES

N#CC1=CC=C2N(C(C3=CC=C(OC)C(O)=C3)=O)C4=C(C=CC=C4)OC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. [Content Brief]