Tubulin polymerization-IN-10

Cat. No.: HY-146863: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-10 Chemical Structure

CAS No. : 2238784-19-3

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Tubulin polymerization-IN-10 is a potent tubulin polymerization inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.606 μM Compound: 12m	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30176537]
A549	IC₅₀	606 nM Compound: 16a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]
HCT-8	IC₅₀	0.332 μM Compound: 4	Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HepG2	IC₅₀	0.217 μM Compound: 4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
HepG2	IC₅₀	0.217 μM Compound: 12m	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30176537]
HepG2	IC₅₀	217 nM Compound: 16a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]
HUVEC	IC₅₀	4.25 μM Compound: 16a	Antitubulin activity against HUVEC assessed as morphological changes of tube incubated for 6 hrs by inverted microscope Antitubulin activity against HUVEC assessed as morphological changes of tube incubated for 6 hrs by inverted microscope	[PMID: 35305462]
K562	IC₅₀	0.128 μM Compound: 4	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 32853870]
K562	IC₅₀	0.128 μM Compound: 12m	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30176537]
K562	IC₅₀	128 nM Compound: 16a	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35305462]

Molecular Weight

379.43

Formula

C₁₈H₂₁NO₆S

CAS No.

2238784-19-3

SMILES

NC1=CC(/C=C/S(=O)(C2=CC(OC)=C(OC)C(OC)=C2)=O)=CC=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huajian Zhu, et al. Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem . 2020 Dec 1;207:112716. [Content Brief]