Tubulin polymerization-IN-16

Cat. No.: HY-146311: FAQs
Data Sheet Handling Instructions Technical Support

Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC₅₀ values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells.

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Tubulin polymerization-IN-16 Chemical Structure

CAS No. : 2296731-38-7

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.133 μM Compound: 5g	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]
HeLa	IC₅₀	0.221 μM Compound: 5g	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]
SGC-7901	IC₅₀	0.084 μM Compound: 5g	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay	[PMID: 31740055]

Molecular Weight

465.50

Formula

C₂₄H₂₇N₅O₅

CAS No.

2296731-38-7

SMILES

COC1=CC(C(C2=NN(N=C2N3CCN(CC3)C(C)=O)C4=CC=CC=C4)=O)=CC(OC)=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang L, et al. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020;186:111846. [Content Brief]