2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-35

Tubulin polymerization-IN-35 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-35 Chemical Structure

Tubulin polymerization-IN-35 Chemical Structure

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Tubulin polymerization-IN-35 Related Antibodies

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Description

Tubulin polymerization-IN-35 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line[1].

IC50 & Target

[1,2]oxazoloisoindoles tubulin polymerization[1]
In Vitro

Tubulin polymerization-IN-35 (compound 17j) (10 nM-100 μM; 72 h) has antiproliferative activity against 9 NCI subpanels (leukemia, non-small-cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate, breast) with GI50s ranging from 0.24 μM to 23.4 μM, and a mean graph_mid point (MG_MID) values of 1.32 μM[1].
Tubulin polymerization-IN-35 (0.15-10 μM; 72 h) shows potent growth inhibitory effects on different lymphoma lines, and demonstrates high selectivity against the VL51 cell line (Marginal zone lymphoma, IC50=0.15 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-35 Related Antibodies

Cell Viability Assay[1]

Cell Line: Marginal zone lymphoma, mantle cell lymphoma, activated B-cell like diffuse large B cell lymphoma, germinal center B-cell-like diffuse large B cell lymphoma cells
Concentration: 0.15-10 μM
Incubation Time: 72 h
Result: Inhibited different lymphomas, with IC50s of 0.15 μM (Marginal zone lymphoma); 0.5 μM (mantle cell lymphoma); 0.6 μM (activated B-cell like diffuse large B cell lymphoma); 0.7 μM (germinal center B-cell-like diffuse large B cell lymphoma), respectively.
Molecular Weight

529.63

Formula

C31H35N3O5
SMILES

COC1=C(OC)C(OC)=CC(C2=C3CCC4=C(ON=C4CN5CCCC5)C3=CN2CC6=CC=C(OC)C=C6)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization-IN-35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-35Microtubule/TubulinMarginal zone lymphomaMZLmantle cell lymphomaMCLactivated B-cell like diffuse large B cell lymphomaABC-DLBCLgerminal center B-cell-like diffuse large B cell lymphomaGCBDLBCLoxazoloisoindoles tubulin polymerizationInhibitorinhibitorinhibit

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