2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-65

Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest.

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Tubulin polymerization-IN-65 Chemical Structure

Tubulin polymerization-IN-65 Chemical Structure

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Tubulin polymerization-IN-65 Related Antibodies

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Description

Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest[1].

In Vitro

Tubulin polymerization-IN-65 (compound 64; 5 μM; 24 h) induces G2 + M cell cycle arrest[1].
Tubulin polymerization-IN-65 (72 h) inhibits cell growth of HT29, U87, MC-7, A2780, H460, A431, Du145, BE2-C, SJ-G2, MIA, MCF10A,with GI50 values of 0.26 μM,1.4 μM, 0.35 μM, 0.33 μM, 0.42 μM, 0.33 μM, 0.90 μM, 0.31 μM, 0.79 μM, 0.37 μM, and, 0.56 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-65 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MIA pancreatic cancer cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Induced G2 + M cell cycle arrest.
Molecular Weight

278.31

Formula

C17H14N2O2
SMILES

O=C1NC(/C=C/C2=CC=CC=C2OC)=NC3=CC=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization-IN-65 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-65Microtubule/Tubulintubulin polymerisation inhibitorsub micromolar cytotoxicityG2 + M cell cycle arrestInhibitorinhibitorinhibit

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