2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-69

Tubulin polymerization-IN-69 (compund 6c) significantly inhibits microtubule/tubulin polymerization in vitro (78.3% inhibition) with an IC50 value of 6.53 μM, and rapidly induces apoptotic cell death and G2/M cell cycle arrest in MCF-7 cells.

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Tubulin polymerization-IN-69 Chemical Structure

Tubulin polymerization-IN-69 Chemical Structure

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Tubulin polymerization-IN-69 Related Antibodies

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Description

Tubulin polymerization-IN-69 (compund 6c) significantly inhibits microtubule/tubulin polymerization in vitro (78.3% inhibition) with an IC50 value of 6.53 μM, and rapidly induces apoptotic cell death and G2/M cell cycle arrest in MCF-7 cells[1].

IC50 & Target

Microtubule/Tubulin[1]
Molecular Weight

531.54

Formula

C25H21N7O5S
SMILES

O=C(C1=C2C=CC=C1)N(CC3=CN(CCC(NC4=CC=C(S(=O)(NC5=NC=CC=C5)=O)C=C4)=O)N=N3)C2=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Tubulin polymerization-IN-69 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-69Microtubule/TubulinInhibitorinhibitorinhibit

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