2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FLT3 Apoptosis
  4. Tuspetinib hydrate

Tuspetinib hydrate  (Synonyms: HM43239 hydrate)

Cat. No.: HY-145015A
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Tuspetinib (HM43239) hydrate is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib hydrate inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib hydrate inhibits the proliferation and induces the apoptosis of leukemic cells.

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Tuspetinib hydrate Chemical Structure

Tuspetinib hydrate Chemical Structure

CAS No. : 2758339-04-5

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Description

Tuspetinib (HM43239) hydrate is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib hydrate inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib hydrate inhibits the proliferation and induces the apoptosis of leukemic cells[1][2][3].

IC50 & Target

IC50: 1.1 nM (FLT3 WT); 1.8 nM (FLT3 ITD); 1.0 nM (FLT3 D835Y)[1].
Molecular Weight

519.08

Formula

C29H35ClN6O
CAS No.
SMILES

ClC1=CN=C(NC2=CC(C3CC3)=CC(CN4C[C@H](N[C@H](C4)C)C)=C2)N=C1C5=CNC6=CC(C)=CC=C56.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tuspetinib hydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tuspetinib2758339-04-5HM43239HM 43239HM-43239FLT3ApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3acute myeloid leukemiaMV-4-11 cellMOLM-13 cellKG-1a cellInhibitorinhibitorinhibit

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