2. Immunology/Inflammation
  3. PD-1/PD-L1 CTLA-4
  4. Tuvonralimab

Tuvonralimab  (Synonyms: PSB-205; QL1706 (iparomlimab/tuvonralimab); PBS105)

Cat. No.: HY-P99540 Purity: 99.14%
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Tuvonralimab (PSB-205; QL1706) is a dual immune checkpoint blockade containing a mixture of anti-PD-1 IgG4 and anti-CTLA-4 IgG1 antibodies, Iparomlimab and Tuvonralimab.

For research use only. We do not sell to patients.

CAS No. : 2417649-44-4

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5 mg USD 900 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Tuvonralimab Related Antibodies

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Description

Tuvonralimab (PSB-205; QL1706) is a dual immune checkpoint blockade containing a mixture of anti-PD-1 IgG4 and anti-CTLA-4 IgG1 antibodies, Iparomlimab and Tuvonralimab[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Tuvonralimab contains mutations for heavy and light chain pairing (HC mutations K147D/F170C/V173C/C220G/R255K/D399R/K409E; light chain mutations S131K/Q160C/S162C/C214S), but not for the generation of a bispecific antibody. The final drug substance is a mixture of two monospecific IgGs, Iparomlimab and Tuvonralimab. The two antibodies are produced from the same cell line, with the mutations within Tuvonralimab ensuring efficient pairing of the correct chains. Iparomlimab contains no mutations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tuvonralimab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tuvonralimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Tuvonralimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tuvonralimab2417649-44-4PSB-205 QL1706 (iparomlimab/tuvonralimab) PBS105PSB205PSB 205PBS105PBS 105PBS-105PD-1/PD-L1CTLA-4PD-1/Programmed death-ligand 1Cytotoxic T-lymphocyte-associated protein 4CD152PD-1immune checkpoint blockadeInhibitorinhibitorinhibit

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