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TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

For research use only. We do not sell to patients.

TWS119 TFA Chemical Structure

TWS119 TFA Chemical Structure

CAS No. : 1507095-58-0

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Top Publications Citing Use of Products

    TWS119 TFA purchased from MedChemExpress. Usage Cited in: FASEB J. 2023 Mar;37(3):e22821.  [Abstract]

    TWS119 substantially increases NF-κB phosphorylation in NK-92 cells.
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    Description

    TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

    Molecular Weight

    546.38

    Formula

    C22H16F6N4O6

    CAS No.
    SMILES

    OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    TWS119 TFA Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    TWS119 TFA
    Cat. No.:
    HY-110074
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