2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. TX2-120-1

TX2-120-1 possesses the ability to bind to Her3, with an IC50 value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998).

For research use only. We do not sell to patients.

TX2-120-1 Chemical Structure

TX2-120-1 Chemical Structure

CAS No. : 1603845-45-9

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TX2-120-1 Related Antibodies

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Description

TX2-120-1 possesses the ability to bind to Her3, with an IC50 value of 56 nM for Her3. TX2-120-1 can be used for the synthesis of TX2-121-1 (HY-118998)[1].

IC50 & Target

IC50: 56 nM (Her3)[1].
In Vivo

TX2-120-1 (0.5-2 μM; 12 h), due to the absence of the hydrophobic adamantane group, exhibits poorer efficacy in inducing Her3 degradation or blocking Her3-dependent signaling in PC9 GR4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

469.54

Formula

C26H27N7O2
CAS No.
SMILES

CN1CCC(N2C3=NC=NC(N)=C3C(C(C=C4)=CC(NC(C=C)=O)=C4OC5=CC=CC=C5)=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TX2-120-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX2-120-11603845-45-9EGFREpidermal growth factor receptorErbB-1HER1PROTACshydrophobic adamantane groupInhibitorinhibitorinhibit

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TX2-120-1
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HY-164988
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