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  4. Tyropeptin A-4

Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity.

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Tyropeptin A-4 Chemical Structure

Tyropeptin A-4 Chemical Structure

CAS No. : 688737-89-5

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Tyropeptin A-4 Related Antibodies

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Description

Tyropeptin A-4 (TP-101) is a potent proteasome inhibitor with the ability to inhibit mammalian 20S proteasome activity. Tyropeptin A-4 exerts its inhibitory effect by binding to the site responsible for trypsin-like activity. Tyropeptin A-4 derivative TP-104 has a 20-fold increase in inhibitory activity over Tyropeptin A. TP-110 specifically inhibits trypsin-like activity without affecting PGPH and trypsin-like activity[1].

Molecular Weight

551.67

Formula

C31H41N3O6
CAS No.
SMILES

OC(C=C1)=CC=C1C[C@H](NC(CC2CCCCC2)=O)C(N[C@@H](C(C)C)C(NC(C=O)CC3=CC=C(C=C3)O)=O)=O
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Tyropeptin A-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyropeptin A-4688737-89-5TP-101Tyropeptin A4Tyropeptin A 4TP101TP 101OthersInhibitorinhibitorinhibit

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