2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. Tyrosine kinase-IN-8

Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia.

For research use only. We do not sell to patients.

Tyrosine kinase-IN-8 Chemical Structure

Tyrosine kinase-IN-8 Chemical Structure

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Tyrosine kinase-IN-8 Related Antibodies

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Description

Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia[1].

IC50 & Target

Abl1

0.8 μM (CC50)

In Vitro

Tyrosine kinase-IN-8 (1 and 10 µM, 48 h) shows the best anti-leukemia activity in the K562 cell lines, but is also more toxic to WSS-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrosine kinase-IN-8 Related Antibodies

Cell Viability Assay[1]

Cell Line: K562 cells and WSS-1 cells
Concentration: 1 and 10 µM
Incubation Time: 48 h
Result: Reduced cell activity at 10μM but had no obvious cytotoxicity at 1μM.
Molecular Weight

561.54

Formula

C31H21F2N7O2
SMILES

CC(C=CC(N1C(C2=CC=C(F)C=C2)=NOC13C(C=C(F)C=C4)=C4NC3=O)=C5)=C5NC6=NC(C7=CC=CN=C7)=CC=N6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tyrosine kinase-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosine kinase-IN-8Bcr-AblTyrosine kinase inhibitorchronic myeloid leukemiaK562 cellsWSS-1 cellsInhibitorinhibitorinhibit

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Tyrosine kinase-IN-8
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HY-162489
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