2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. TZD18

TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes.

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TZD18 Chemical Structure

TZD18 Chemical Structure

CAS No. : 228577-00-2

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TZD18 Related Antibodies

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Description

TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes[1].

IC50 & Target[1]

hPPARα

0.028 μM (IC50)

hPPARγ

0.057 μM (IC50)

PPARδ

>10 μM (IC50)

In Vivo

TZD18 (3, 10 mg/kg; p.o.; daily for 11 days) completes the correction of elevated plasma levels of both glucose and triglycerides in diabetic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12-13 weeks, Male db/db and nondiabetic db/+ (lean) mice (type 2 diabetes) [1]
Dosage: 3, 10 mg/kg
Administration: P.o.; daily for 11 days
Result: Reduced hyperglycemia and plasma triglyceride levels.
Molecular Weight

477.57

Formula

C27H27NO5S
CAS No.
SMILES

O=C(SC1C2=CC=CC(OCCCOC3=CC=C(C=C3CCC)OC4=CC=CC=C4)=C2)NC1=O
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Purity & Documentation
References
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TZD18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TZD18228577-00-2TZD 18TZD-18PPARPeroxisome proliferator-activated receptorsglucosetriglyceridesorally activetype 2 diabetesInhibitorinhibitorinhibit

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