TZD18

Cat. No.: HY-121798: FAQs
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TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC₅₀ values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes.

For research use only. We do not sell to patients.

TZD18 Chemical Structure

CAS No. : 228577-00-2

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

hPPARα

0.028 μM (IC₅₀)

hPPARγ

0.057 μM (IC₅₀)

PPARδ

>10 μM (IC₅₀)

In Vivo

TZD18 (3, 10 mg/kg; p.o.; daily for 11 days) completes the correction of elevated plasma levels of both glucose and triglycerides in diabetic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	12-13 weeks, Male db/db and nondiabetic db/+ (lean) mice (type 2 diabetes) ^[1]
Dosage:	3, 10 mg/kg
Administration:	P.o.; daily for 11 days
Result:	Reduced hyperglycemia and plasma triglyceride levels.

Molecular Weight

477.57

Formula

C₂₇H₂₇NO₅S

CAS No.

228577-00-2

SMILES

O=C(SC1C2=CC=CC(OCCCOC3=CC=C(C=C3CCC)OC4=CC=CC=C4)=C2)NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo Q, et al. A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis. Endocrinology. 2004 Apr;145(4):1640-8. [Content Brief]

TZD18 Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TZD18228577-00-2TZD 18TZD-18PPARPeroxisome proliferator-activated receptorsglucosetriglyceridesorally activetype 2 diabetesInhibitorinhibitorinhibit

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