2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. UBP 302

UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent Kd=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects.

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UBP 302 Chemical Structure

UBP 302 Chemical Structure

CAS No. : 745055-91-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 477 Get quote
Solid
5 mg USD 463 In-stock
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Based on 1 publication(s) in Google Scholar

UBP 302 Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent Kd=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects[1][2][3].

IC50 & Target

apparent Kd: 402 nM (GLUK5)[2]
IC50: 106 μM (AMPA receptors)[2]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 300 μM
Compound: 11
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay
[PMID: 17348638]
HEK293 IC50
> 300 μM
Compound: 11
Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay
Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay
[PMID: 17348638]
HEK293 IC50
> 300 μM
Compound: 11
Antagonist activity at human recombinant GLUK6/GLUK2 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay
Antagonist activity at human recombinant GLUK6/GLUK2 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay
[PMID: 17348638]
Molecular Weight

333.30

Formula

C15H15N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C=CC1=O)C[C@H](N)C(O)=O)N1CC2=C(C=CC=C2)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (50.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0003 mL 15.0015 mL 30.0030 mL
5 mM 0.6001 mL 3.0003 mL 6.0006 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0003 mL 15.0015 mL 30.0030 mL 75.0075 mL
5 mM 0.6001 mL 3.0003 mL 6.0006 mL 15.0015 mL
10 mM 0.3000 mL 1.5002 mL 3.0003 mL 7.5008 mL
15 mM 0.2000 mL 1.0001 mL 2.0002 mL 5.0005 mL
20 mM 0.1500 mL 0.7501 mL 1.5002 mL 3.7504 mL
25 mM 0.1200 mL 0.6001 mL 1.2001 mL 3.0003 mL
30 mM 0.1000 mL 0.5001 mL 1.0001 mL 2.5003 mL
40 mM 0.0750 mL 0.3750 mL 0.7501 mL 1.8752 mL
50 mM 0.0600 mL 0.3000 mL 0.6001 mL 1.5002 mL
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UBP 302 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UBP 302745055-91-8UBP302UBP-302iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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