2. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. AMPK JAK
  4. UCB9386

UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM.

For research use only. We do not sell to patients.

UCB9386 Chemical Structure

UCB9386 Chemical Structure

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UCB9386 Related Antibodies

Top Publications Citing Use of Products

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM[1].

Molecular Weight

478.55

Formula

C27H26N8O
SMILES

C[C@H](C1=CC=CC=C1)N(C(C(N2CC3(CN(C)C3)C2)=N4)=O)C5=C4C=NC(C6=CN=C7C=CC=NN76)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UCB9386 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCB9386UCB 9386UCB-9386AMPKJAKAMP-activated protein kinaseJanus kinaseselectivebrain penetrantBALB/c mouseInhibitorinhibitorinhibit

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