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UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties.

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UHMCP1 Chemical Structure

UHMCP1 Chemical Structure

CAS No. : 2103079-87-2

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UHMCP1 Related Antibodies

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Description

UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties[1].

IC50 & Target

Kd: 79 µM (UHM domain)[1]
In Vitro

UHMCP1 (25-400 μM) reduces the binding of purified U2AF65 to SF3b155 by 75%, exhibiting a simple, non-cooperative binding mode with Kd around 30 μM for U2AF65[1].
UHMCP1 (0-200 μM; 24 h) exhibits a certain effect on cell viability of HEK293[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UHMCP1 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited cell viability with an EC50 value of 140 µM.
Molecular Weight

297.44

Formula

C19H27N3
CAS No.
SMILES

CC(N(C[C@]1([H])CC2)C[C@]2([H])[C@H]1N)CCC3=CNC4=CC=CC=C34
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UHMCP1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UHMCP12103079-87-2UHMCP 1UHMCP-1OthersHEK293 cellsRNA splicinganticancerU2AF65/SF3b155 interactionInhibitorinhibitorinhibit

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