UHMCP1

Cat. No.: HY-148384: FAQs
Data Sheet Handling Instructions

Molarity Calculator

UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a K_d of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties.

For research use only. We do not sell to patients.

UHMCP1 Chemical Structure

CAS No. : 2103079-87-2

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of UHMCP1:

UHMCP1 dihydrochloride Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

K_d: 79 µM (UHM domain)^[1]

In Vitro

UHMCP1 (25-400 μM) reduces the binding of purified U2AF⁶⁵ to SF3b155 by 75%, exhibiting a simple, non-cooperative binding mode with K_d around 30 μM for U2AF⁶⁵^[1].
UHMCP1 (0-200 μM; 24 h) exhibits a certain effect on cell viability of HEK293^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HEK293 cells
Concentration:	0-100 µM
Incubation Time:	24 h
Result:	Inhibited cell viability with an EC₅₀ value of 140 µM.

Molecular Weight

297.44

Formula

C₁₉H₂₇N₃

CAS No.

2103079-87-2

SMILES

CC(N(C[C@]1([H])CC2)C[C@]2([H])[C@H]1N)CCC3=CNC4=CC=CC=C34

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kobayashi A, et al. Identification of a small molecule splicing inhibitor targeting UHM domains. FEBS J. 2022 Feb;289(3):682-698. [Content Brief]

UHMCP1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UHMCP12103079-87-2UHMCP 1UHMCP-1OthersHEK293 cellsRNA splicinganticancerU2AF65/SF3b155 interactionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks