UNC10142

Cat. No.: HY-159989: FAQs
Data Sheet Handling Instructions

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UNC10142 (Compound 44) is a first-in-class small molecule antagonist of CHD1 that binds with an IC₅₀ value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells.

For research use only. We do not sell to patients.

UNC10142 Chemical Structure

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Description	UNC10142 (Compound 44) is a first-in-class small molecule antagonist of CHD1 that binds with an IC₅₀ value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells^[1].
Molecular Weight	580.80
Formula	C₃₃H₅₂N₆O₃
SMILES	COC1=C(OCCCN2CCCCC2)C=C(N=C(N3CCCCCCCC3)N=C4N(C)C5CCN(C(C)=O)CC5)C4=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Johnson RL, et al. Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer. J Med Chem. 2024 Nov 28;67(22):20056-20075. [Content Brief]

UNC10142 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC10142UNC 10142UNC-10142Epigenetic Reader DomainCHD1PTENprostate cancer cellsInhibitorinhibitorinhibit

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UNC10142

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