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UNC8732 is a targeted protein degradation (TPD) agent. It generates aldehyde metabolites through amine oxidase catalysis, which bind to C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. The recruited FBXO22 further induces degradation of histone methyltransferases and the oncogene NSD2.

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UNC8732 Chemical Structure

UNC8732 Chemical Structure

CAS No. : 2929304-05-0

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Description

UNC8732 is a targeted protein degradation (TPD) agent. It generates aldehyde metabolites through amine oxidase catalysis, which bind to C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. The recruited FBXO22 further induces degradation of histone methyltransferases and the oncogene NSD2[1].

Molecular Weight

609.71

Formula

C35H39N5O5

CAS No.
SMILES

O=C(N1)COC2=C1C=CC(C(N(C3CC3)CC4=CC=C(C(NC5=CC=C(CN(C(CCCCCN)=O)CC6)C6=C5)=O)C=C4)=O)=C2

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UNC8732
Cat. No.:
HY-161796
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