1. Protein Tyrosine Kinase/RTK
  2. Ephrin Receptor
  3. UniPR1454

UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC50 of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251.

For research use only. We do not sell to patients.

UniPR1454 Chemical Structure

UniPR1454 Chemical Structure

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Description

UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC50 of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251[1].

IC50 & Target

EphA2

2.6 μM (IC50)

EphA4

4.2 μM (IC50)

EphA3

7.6 μM (IC50)

EphA5

9.3 μM (IC50)

EphA6

10 μM (EC50)

EphA1

11 μM (IC50)

EphA8

13 μM (IC50)

EphA7

15 μM (IC50)

Molecular Weight

782.95

Formula

C43H53F3N2O6S

SMILES

C[C@]12[C@]([H])([C@]3([C@@]([H])([C@]4(C)C(C[C@@H](O)CC4)=CC3)CC2)[H])CC[C@@]1([C@@H](CCC(N[C@H](CC(O)=O)CC5=CN(C6=C5C=CC=C6)S(=O)(C7=CC=C(C=C7)C(F)(F)F)=O)=O)C)[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UniPR1454
Cat. No.:
HY-163835
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