UniPR1454

Cat. No.: HY-163835: FAQs
Data Sheet Handling Instructions

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UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC₅₀ of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251.

For research use only. We do not sell to patients.

UniPR1454 Chemical Structure

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MOQ		Minimum order quantity
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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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•Related Small Molecules:

•Related Proteins:

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EphA2 EphA3 EphA4

Biological Activity
Purity & Documentation
References
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Description

UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC₅₀ of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251^[1].

IC₅₀ & Target

EphA2

2.6 μM (IC₅₀)

EphA4

4.2 μM (IC₅₀)

EphA3

7.6 μM (IC₅₀)

EphA5

9.3 μM (IC₅₀)

EphA6

10 μM (EC₅₀)

EphA1

11 μM (IC₅₀)

EphA8

13 μM (IC₅₀)

EphA7

15 μM (IC₅₀)

Molecular Weight

782.95

Formula

C₄₃H₅₃F₃N₂O₆S

SMILES

C[C@]12[C@]([H])([C@]3([C@@]([H])([C@]4(C)C(C[C@@H](O)CC4)=CC3)CC2)[H])CC[C@@]1([C@@H](CCC(N[C@H](CC(O)=O)CC5=CN(C6=C5C=CC=C6)S(=O)(C7=CC=C(C=C7)C(F)(F)F)=O)=O)C)[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guidetti L, et al., Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line. Eur J Med Chem. 2024 Jul 15;276:116681. [Content Brief]

UniPR1454 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UniPR1454UniPR 1454UniPR-1454Ephrin ReceptorU251glioblastomaInhibitorinhibitorinhibit

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