2. Neuronal Signaling
  3. Dopamine Transporter Serotonin Transporter
  4. UWA-101 hydrochloride

UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease.

For research use only. We do not sell to patients.

UWA-101 hydrochloride Chemical Structure

UWA-101 hydrochloride Chemical Structure

CAS No. : 1431520-52-3

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UWA-101 hydrochloride Related Antibodies

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Description

UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease[1][2].

In Vivo

UWA-101 hydrochloride (3 mg/kg; i.p.; single) reduces L-DOPA-induced dyskinesia in Parkinson's disease rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g; Parkinson's disease model)[1].
Dosage: 3 mg/kg
Administration: Intraperitoneal injection
Result: Reduced L-DOPA-induced vertical activity by 60%.
Molecular Weight

255.74

Formula

C13H18ClNO2
CAS No.
SMILES

CNC(C1CC1)CC2=CC=C3OCOC3=C2.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UWA-101 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UWA-1011431520-52-3UWA101UWA 101Dopamine TransporterSerotonin TransporterDATSLC6A35-HTTSERTSLC6A4Parkinson'sneurodegenerative diseases5-HTdopamineInhibitorinhibitorinhibit

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