Uzarigenin (Synonyms: NSC 119993; NSC 277290; Odorigeni)

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Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively.

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Uzarigenin Chemical Structure

CAS No. : 466-09-1

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	3.9 μM Compound: 1	Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32649211]
Calu-1	IC₅₀	8 μM Compound: 23	Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay	[PMID: 30629433]
HeLa	IC₅₀	3 μM Compound: 23	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30629433]
Hs-578T	IC₅₀	3.6 μM Compound: 1	Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32649211]
MCF7	IC₅₀	6 μM Compound: 23	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30629433]
MDA-MB-231	IC₅₀	> 30 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32649211]
PC-3	IC₅₀	0.3 μM Compound: 23	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 30629433]
U-251	IC₅₀	6 μM Compound: 23	Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay	[PMID: 30629433]

Molecular Weight

374.51

Formula

C₂₃H₃₄O₄

CAS No.

466-09-1

SMILES

O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=C1

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79. [Content Brief]

Uzarigenin Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uzarigenin466-09-1NSC 119993 NSC 277290 OdorigeniNSC119993NSC-119993NSC277290NSC 277290NSC-277290Othersantiproliferative activityInhibitorinhibitorinhibit

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