Vacquinol-1 (Synonyms: NSC13316)

Cat. No.: HY-19345: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Vacquinol-1 dihydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Vacquinol-1 Chemical Structure

CAS No. : 5428-80-8

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Vacquinol-1:

Vacquinol-1 dihydrochloride Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways^[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model^[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
U3013MG	IC₅₀	3.14 μM Compound: 1	Cytotoxicity against patient-derived U3013MG cells assessed as reduction in cell viability by Celltiter-Glo reagent based assay Cytotoxicity against patient-derived U3013MG cells assessed as reduction in cell viability by Celltiter-Glo reagent based assay	[PMID: 27607569]

Molecular Weight

352.86

Formula

C₂₁H₂₁ClN₂O

CAS No.

5428-80-8

SMILES

OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (85.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8340 mL	14.1699 mL	28.3399 mL
5 mM	0.5668 mL	2.8340 mL	5.6680 mL
10 mM	0.2834 mL	1.4170 mL	2.8340 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [Content Brief]

[2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. [Content Brief]

[3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881. [Content Brief]

[4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. [Content Brief]

[5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8340 mL	14.1699 mL	28.3399 mL	70.8496 mL
	5 mM	0.5668 mL	2.8340 mL	5.6680 mL	14.1699 mL
	10 mM	0.2834 mL	1.4170 mL	2.8340 mL	7.0850 mL
	15 mM	0.1889 mL	0.9447 mL	1.8893 mL	4.7233 mL
	20 mM	0.1417 mL	0.7085 mL	1.4170 mL	3.5425 mL
	25 mM	0.1134 mL	0.5668 mL	1.1336 mL	2.8340 mL
	30 mM	0.0945 mL	0.4723 mL	0.9447 mL	2.3617 mL
	40 mM	0.0708 mL	0.3542 mL	0.7085 mL	1.7712 mL
	50 mM	0.0567 mL	0.2834 mL	0.5668 mL	1.4170 mL
	60 mM	0.0472 mL	0.2362 mL	0.4723 mL	1.1808 mL
	80 mM	0.0354 mL	0.1771 mL	0.3542 mL	0.8856 mL

Vacquinol-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vacquinol-15428-80-8NSC13316Vacquinol1Vacquinol 1NSC 13316NSC-13316OthersMKK4-specific activatoractivates MAPK pathwaysglioblastomaglioblastoma multiformeinduces apoptosishepatocellular carcinomaHCCInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks