2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Val-Cit

Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Val-Cit Chemical Structure

Val-Cit Chemical Structure

CAS No. : 159858-33-0

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5 mg USD 290 In-stock
10 mg USD 420 In-stock
25 mg USD 780 In-stock
50 mg USD 1150 In-stock
100 mg USD 1750 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Val-Cit Related Antibodies

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Description

Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Protease Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Val-Cit Related Antibodies
Molecular Weight

274.32

Formula

C11H22N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (227.84 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6454 mL 18.2269 mL 36.4538 mL
5 mM 0.7291 mL 3.6454 mL 7.2908 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6454 mL 18.2269 mL 36.4538 mL 91.1344 mL
5 mM 0.7291 mL 3.6454 mL 7.2908 mL 18.2269 mL
10 mM 0.3645 mL 1.8227 mL 3.6454 mL 9.1134 mL
15 mM 0.2430 mL 1.2151 mL 2.4303 mL 6.0756 mL
20 mM 0.1823 mL 0.9113 mL 1.8227 mL 4.5567 mL
25 mM 0.1458 mL 0.7291 mL 1.4582 mL 3.6454 mL
30 mM 0.1215 mL 0.6076 mL 1.2151 mL 3.0378 mL
40 mM 0.0911 mL 0.4557 mL 0.9113 mL 2.2784 mL
50 mM 0.0729 mL 0.3645 mL 0.7291 mL 1.8227 mL
60 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5189 mL
80 mM 0.0456 mL 0.2278 mL 0.4557 mL 1.1392 mL
100 mM 0.0365 mL 0.1823 mL 0.3645 mL 0.9113 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Val-Cit Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Val-Cit159858-33-0ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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