Valopicitabine (Synonyms: NM283)

Cat. No.: HY-108060: FAQs
Data Sheet Handling Instructions Technical Support

Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Valopicitabine dihydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Valopicitabine Chemical Structure

CAS No. : 640281-90-9

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Other Forms of Valopicitabine:

Valopicitabine dihydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

HCV^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	> 100 μM Compound: valopicitabaine	Cytotoxicity against Huh7 cells after 24 hrs by MTS assay Cytotoxicity against Huh7 cells after 24 hrs by MTS assay	[PMID: 17521911]
Huh-7	EC₅₀	1.5 μM Compound: valopicitabaine	Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay	[PMID: 17521911]
Huh-7	EC₅₀	7.45 μM Compound: valopicitabaine	Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay	[PMID: 17521911]
Huh-7	EC₅₀	7.6 μM Compound: 1	Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay	[PMID: 19493593]

In Vivo

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) shows the C_max, AUC, t_1/2, and t_max were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

356.37

Formula

C₁₅H₂₄N₄O₆

CAS No.

640281-90-9

SMILES

C[C@@]1([C@@](N2C(N=C(C=C2)N)=O)([H])O[C@@H]([C@H]1OC([C@@H](N)C(C)C)=O)CO)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. [Content Brief]

[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20. [Content Brief]

Valopicitabine Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valopicitabine640281-90-9NM283NM 283NM-283HCVHCV ProteaseNucleoside Antimetabolite/AnalogHepatitis C virusprodrugoralnucleosideanalogchainterminationpolymeraseInhibitorinhibitorinhibit

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