2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. vc-PABC-DM1

vc-PABC-DM1 used to synthesize an ADC molecule based on utilize disulfide linker. vc-PABC-DM1 can be used to explore serum stability.

For research use only. We do not sell to patients.

vc-PABC-DM1 Chemical Structure

vc-PABC-DM1 Chemical Structure

CAS No. : 1416792-90-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1754 In-stock
Solution
10 mM * 1 mL in DMSO USD 1754 In-stock
Solid
1 mg USD 360 In-stock
5 mg USD 910 In-stock
10 mg USD 1450 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

vc-PABC-DM1 Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

View All Isoforms
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

vc-PABC-DM1 used to synthesize an ADC molecule based on utilize disulfide linker. vc-PABC-DM1 can be used to explore serum stability[1].

Molecular Weight

1099.73

Formula

C53H75ClN8O13S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCSCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (90.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9093 mL 4.5466 mL 9.0931 mL
5 mM 0.1819 mL 0.9093 mL 1.8186 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9093 mL 4.5466 mL 9.0931 mL 22.7329 mL
5 mM 0.1819 mL 0.9093 mL 1.8186 mL 4.5466 mL
10 mM 0.0909 mL 0.4547 mL 0.9093 mL 2.2733 mL
15 mM 0.0606 mL 0.3031 mL 0.6062 mL 1.5155 mL
20 mM 0.0455 mL 0.2273 mL 0.4547 mL 1.1366 mL
25 mM 0.0364 mL 0.1819 mL 0.3637 mL 0.9093 mL
30 mM 0.0303 mL 0.1516 mL 0.3031 mL 0.7578 mL
40 mM 0.0227 mL 0.1137 mL 0.2273 mL 0.5683 mL
50 mM 0.0182 mL 0.0909 mL 0.1819 mL 0.4547 mL
60 mM 0.0152 mL 0.0758 mL 0.1516 mL 0.3789 mL
80 mM 0.0114 mL 0.0568 mL 0.1137 mL 0.2842 mL
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vc-PABC-DM1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

vc-PABC-DM11416792-90-9ADC LinkerAntibody-drug conjugates linkerADC moleculeutilize disulfide linkerserumInhibitorinhibitorinhibit

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