VEGFR-2/BRAF-IN-2

Cat. No.: HY-146492: FAQs
Data Sheet Handling Instructions

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VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC₅₀ values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAF^V600E and BRAF^WT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase.

For research use only. We do not sell to patients.

VEGFR-2/BRAF-IN-2 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

BRAF^WT

0.071 μM (IC₅₀)

BRaf^V600E

0.089 μM (IC₅₀)

VEGFR2

0.111 μM (IC₅₀)

Molecular Weight

608.05

Formula

C₂₆H₂₁ClF₃N₅O₃S₂

SMILES

FC(F)(F)C1=CC=CC(NC(NNC(CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O)=O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hassan RA, et al. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2022 May 10;125:105861. [Content Brief]

VEGFR-2/BRAF-IN-2 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2/BRAF-IN-2VEGFRRafApoptosisVascular endothelial growth factor receptorRaf kinasesanticancercaspase-9MCF7Inhibitorinhibitorinhibit

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