2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. VEGFR-2-IN-11

VEGFR-2-IN-11 (Compound 8h) is a potent VEGFR-2 inhibitor with an IC50 of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cell apoptosis.

For research use only. We do not sell to patients.

VEGFR-2-IN-11 Chemical Structure

VEGFR-2-IN-11 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

VEGFR-2-IN-11 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VEGFR-2-IN-11 (Compound 8h) is a potent VEGFR-2 inhibitor with an IC50 of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cell apoptosis[1].

IC50 & Target

VEGFR-2

60.27 nM (IC50)

In Vitro

VEGFR-2-IN-11 (Compound 8h) (0-100 µM) shows antiproliferation activities against tumor cells and induces a low toxic effect in normal cells[1].
VEGFR-2-IN-11 (4.92 µM, 24h) arrests the cell cycle on MCF-7 at a G1/S phase and induces MCF-7 cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-11 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT-116, HEPG-2, and MCF-7
Concentration: 0-100 µM
Incubation Time:
Result: Showed antiproliferation activities with IC50 values of 8.62 ± 0.7, 10.18 ± 0.8, and 4.92 ± 0.2 µM against HCT-116, HEPG-2, and MCF-7 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7
Concentration: 4.92 µM
Incubation Time: 24 h
Result: Resulted in a significant increase in the ratio of MCF-7 cells in the G0/G1 phase from 45.81 % (untreated cells) to 49.18 % and the S phase from 39.14% (untreated cells) to 43.22% with a concomitant decrease in the number of cells in G2/M phase by 7.6% compared to untreated control (15.05%).

Apoptosis Analysis[1]

Cell Line: MCF-7
Concentration: 4.92 µM
Incubation Time: 24 h
Result: Induced the early apoptosis in MCF-7 (3.46%) 6.4 folds over the untreated cells (0.54%). Enhanced the late apoptotic induction by 20.72% compared to untreated control (0.18%). Induced total apoptosis with 36.24%.

Cell Cytotoxicity Assay[1]

Cell Line: WI-38
Concentration: 0-100 µM
Incubation Time:
Result: Induced a low toxic effect with an IC50 value of 44.45 ± 3.2 µM against WI-38 cells.
Molecular Weight

552.49

Formula

C29H22BrN5S
SMILES

S=C(NC1=CC=C(C=C1)NC2=NC(/C=C/C3=CC=C(C=C3)Br)=NC4=CC=CC=C42)NC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

VEGFR-2-IN-11 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-11VEGFRApoptosisVascular endothelial growth factor receptorantitumorHCT-116HEPG-2MCF-7Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
VEGFR-2-IN-11
Cat. No.:
HY-145856
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.