VEGFR-2-IN-14

Cat. No.: HY-144795: FAQs
Data Sheet Handling Instructions

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VEGFR-2-IN-14 (Compound 5) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-14 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis.

For research use only. We do not sell to patients.

VEGFR-2-IN-14 Chemical Structure

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

Biological Activity
Purity & Documentation
References
Customer Review

Description

VEGFR-2-IN-14 (Compound 5) is a potent VEGFR-2 inhibitor. VEGFR-2-IN-14 arrests the HepG2 cell growth at the Pre-G1 phase and induces apoptosis^[1].

IC₅₀ & Target

VEGFR2

In Vitro

VEGFR-2-IN-14 (Compound 5) shows cytotoxic activities with IC₅₀ values of 9.7 ± 0.75 µM and 8.8 ± 0.69 µM against MCF-7 and HepG2 cells, respectively^[1].
VEGFR-2-IN-14 shows VEGFR-2 inhibitory effects with concentrations of 610.4 pg/ml^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

433.52

Formula

C₂₄H₂₃N₃O₃S

SMILES

COC1=CC=C2C=C(C=CC2=C1)[C@@H](C3=NN=C(O3)SCC(NCC4=CC=CC=C4)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hagras M, et al. 1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37(1):380-396. [Content Brief]

VEGFR-2-IN-14 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-14VEGFRApoptosisVascular endothelial growth factor receptorHepG2MCF-7caspase-3Inhibitorinhibitorinhibit

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