VEGFR-2-IN-50

Cat. No.: HY-161855: FAQs
Data Sheet Handling Instructions

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VEGFR-2-IN-50 (Compound 10f) is a VEGFR-2 inhibitor and apoptosis inducer, with an IC₅₀ value of 0.33 μM. VEGFR-2-IN-50 (Compound 10f) has growth inhibitory activity on MCF-7 and MDA-MB-231 breast cancer cell lines, with IC₅₀ values of 19.86 μM and 10.88 μM, respectively, which is expected to be used in the study of breast cancer diseases.

For research use only. We do not sell to patients.

VEGFR-2-IN-50 Chemical Structure

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Description	VEGFR-2-IN-50 (Compound 10f) is a VEGFR-2 inhibitor and apoptosis inducer, with an IC₅₀ value of 0.33 μM. VEGFR-2-IN-50 (Compound 10f) has growth inhibitory activity on MCF-7 and MDA-MB-231 breast cancer cell lines, with IC₅₀ values of 19.86 μM and 10.88 μM, respectively, which is expected to be used in the study of breast cancer diseases^[1].
IC₅₀ & Target	IC₅₀: 0.33 μM (VEGFR-2)^[1].
In Vitro	VEGFR-2-IN-50 (Compound 10f) has growth inhibitory activity on MCF-7 and MDA-MB-231 breast cancer cell lines^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. VEGFR-2-IN-50 Related Antibodies
Molecular Weight	458.31
Formula	C₂₃H₁₆BrN₅O
SMILES	O=C1NC2=C(C=C(Br)C=C2)/C1=N/N=C/C3=C(C4=CC=C(C)C=C4)N=C5C=CC=CN53
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Mahmoud S. Elkotamy, et al. Novel imidazo[2,1-b]thiazoles and imidazo[1,2-a]pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and biological evaluations. Bioorganic Chemistry. 2024 Oct; 151: 107644.

VEGFR-2-IN-50 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-50VEGFRApoptosisVascular endothelial growth factor receptorapoptosisMCF-7MDA-MB-231breast cancerInhibitorinhibitorinhibit

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