2. Anti-infection Protein Tyrosine Kinase/RTK
  3. Bacterial VEGFR
  4. VEGFR-2/InhA-IN-1

VEGFR-2/InhA-IN-1 is a pyrazole-based dual inhibitor of InhA-VEGFR with anti-tuberculosis and anti-angiogenic activities. VEGFR-2/InhA-IN-1 has good antibacterial activity against Mycobacterium tuberculosis H37Rv strain (MIC=6.25 μg/mL) and significantly inhibits VEGFR-2 (IC50=15.27 nM).

For research use only. We do not sell to patients.

VEGFR-2/InhA-IN-1 Chemical Structure

VEGFR-2/InhA-IN-1 Chemical Structure

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VEGFR-2/InhA-IN-1 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

VEGFR-2/InhA-IN-1 is a pyrazole-based dual inhibitor of InhA-VEGFR with anti-tuberculosis and anti-angiogenic activities. VEGFR-2/InhA-IN-1 has good antibacterial activity against Mycobacterium tuberculosis H37Rv strain (MIC=6.25 μg/mL) and significantly inhibits VEGFR-2 (IC50=15.27 nM)[1].

IC50 & Target[1]

VEGFR2

15.27 nM (IC50)

Molecular Weight

406.84

Formula

C22H16ClFN4O
SMILES

O=C(NC1=CC=C(F)C=C1)NC2=CN(C3=CC=CC=C3)N=C2C4=CC=C(Cl)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2/InhA-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2/InhA-IN-1BacterialVEGFRVascular endothelial growth factor receptorTuberculosisAntiangiogenesisInhAMycobacterium tuberculosis H37RvInhibitorinhibitorinhibit

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