2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-IN-5

VEGFR-IN-5 (compound 9k) is a potent inhibitor of VEGFR2, with the IC50 of 8.4 nM and an acceptable oral bioavailability. VEGFR-IN-5 inhibits migration and invasion of human umbilical vein endothelial cells (HUVEC) cells and induces apoptosis.

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VEGFR-IN-5 Chemical Structure

VEGFR-IN-5 Chemical Structure

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VEGFR-IN-5 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

VEGFR-IN-5 (compound 9k) is a potent inhibitor of VEGFR2, with the IC50 of 8.4 nM and an acceptable oral bioavailability. VEGFR-IN-5 inhibits migration and invasion of human umbilical vein endothelial cells (HUVEC) cells and induces apoptosis[1].

IC50 & Target

VEGFR2

8.4 nM (IC50)

Molecular Weight

609.04

Formula

C31H28ClF3N6O2
SMILES

COC1=CC2=CC=C(C=C2C=C1C(NC3=CC=C(C(C(F)(F)F)=C3)CN4CCN(CC4)C)=O)C5=CN=C6C=CC(Cl)=NN56
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-IN-5VEGFRVascular endothelial growth factor receptorHT‐29 cellsHUVEC cellsPonatinibSunitinibInhibitorinhibitorinhibit

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