2. Others Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Calcium Channel P-glycoprotein Cytochrome P450
  4. Verapamil-d3 hydrochloride

Verapamil-d3 hydrochloride  (Synonyms: (±)-Verapamil-d3 hydrochloride; CP-16533-1-d3 hydrochloride)

Cat. No.: HY-A0064S Purity: 99.57%
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Verapamil-d3 (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

For research use only. We do not sell to patients.

Verapamil-d<sub>3</sub> hydrochloride Chemical Structure

Verapamil-d3 hydrochloride Chemical Structure

CAS No. : 2714485-49-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Verapamil-d3 hydrochloride:

Verapamil-d3 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Calcium Channel Isoform Specific Products:

View All Isoforms
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Verapamil-d3 (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Verapamil-d3 hydrochloride Related Antibodies
Molecular Weight

494.08

Formula

C27H36D3ClN2O4
CAS No.
Unlabeled CAS

152-11-4
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C([2H])([2H])[2H])C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (101.20 mM; Need ultrasonic)

H2O : 50 mg/mL (101.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0240 mL 10.1198 mL 20.2396 mL
5 mM 0.4048 mL 2.0240 mL 4.0479 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 2.0240 mL 10.1198 mL 20.2396 mL 50.5991 mL
5 mM 0.4048 mL 2.0240 mL 4.0479 mL 10.1198 mL
10 mM 0.2024 mL 1.0120 mL 2.0240 mL 5.0599 mL
15 mM 0.1349 mL 0.6747 mL 1.3493 mL 3.3733 mL
20 mM 0.1012 mL 0.5060 mL 1.0120 mL 2.5300 mL
25 mM 0.0810 mL 0.4048 mL 0.8096 mL 2.0240 mL
30 mM 0.0675 mL 0.3373 mL 0.6747 mL 1.6866 mL
40 mM 0.0506 mL 0.2530 mL 0.5060 mL 1.2650 mL
50 mM 0.0405 mL 0.2024 mL 0.4048 mL 1.0120 mL
60 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.8433 mL
80 mM 0.0253 mL 0.1265 mL 0.2530 mL 0.6325 mL
100 mM 0.0202 mL 0.1012 mL 0.2024 mL 0.5060 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Verapamil-d3 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verapamil-d32714485-49-9(±)-Verapamil-d3CP-16533-1-d3Isotope-Labeled CompoundsCalcium ChannelP-glycoproteinCytochrome P450Ca2+ channelsCa channelsP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsInhibitorinhibitorinhibit

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