Verapamil-d₃ hydrochloride (Synonyms: (±)-Verapamil-d₃ hydrochloride; CP-16533-1-d₃ hydrochloride)

Cat. No.: HY-A0064S Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

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Verapamil-d₃ (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

For research use only. We do not sell to patients.

Verapamil-d<sub>3</sub> hydrochloride Chemical Structure

Verapamil-d₃ hydrochloride Chemical Structure

CAS No. : 2714485-49-9

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1 mg	USD 120	Ask For Quote & Lead Time

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Other Forms of Verapamil-d₃ hydrochloride:

Verapamil hydrochloride In-stock

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View All Isoforms

N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

494.08

Formula

C₂₇H₃₆D₃ClN₂O₄

CAS No.

2714485-49-9

Unlabeled CAS

152-11-4

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C([2H])([2H])[2H])C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (101.20 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0240 mL	10.1198 mL	20.2396 mL
5 mM	0.4048 mL	2.0240 mL	4.0479 mL
10 mM	0.2024 mL	1.0120 mL	2.0240 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (282 KB) RP-HPLC (1571 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746. [Content Brief]

[3]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S. [Content Brief]

[4]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567. [Content Brief]

[5]. Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81. [Content Brief]

[6]. Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O	1 mM	2.0240 mL	10.1198 mL	20.2396 mL	50.5991 mL
	5 mM	0.4048 mL	2.0240 mL	4.0479 mL	10.1198 mL
	10 mM	0.2024 mL	1.0120 mL	2.0240 mL	5.0599 mL
	15 mM	0.1349 mL	0.6747 mL	1.3493 mL	3.3733 mL
	20 mM	0.1012 mL	0.5060 mL	1.0120 mL	2.5300 mL
	25 mM	0.0810 mL	0.4048 mL	0.8096 mL	2.0240 mL
	30 mM	0.0675 mL	0.3373 mL	0.6747 mL	1.6866 mL
	40 mM	0.0506 mL	0.2530 mL	0.5060 mL	1.2650 mL
	50 mM	0.0405 mL	0.2024 mL	0.4048 mL	1.0120 mL
	60 mM	0.0337 mL	0.1687 mL	0.3373 mL	0.8433 mL
	80 mM	0.0253 mL	0.1265 mL	0.2530 mL	0.6325 mL
	100 mM	0.0202 mL	0.1012 mL	0.2024 mL	0.5060 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Verapamil-d₃ hydrochloride Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Verapamil-d3 hydrochloride (Synonyms: (±)-Verapamil-d3 hydrochloride; CP-16533-1-d3 hydrochloride)

Other Forms of Verapamil-d3 hydrochloride:

Verapamil-d3 hydrochloride Related Antibodies

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Biological Activity

Purity & Documentation

References

Customer Review

Verapamil-d3 hydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Verapamil-d3 hydrochloride Related Classifications

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