Vernolide B

Cat. No.: HY-N8900: FAQs
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Vernolide-B has cytoxicity (ED₅₀s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea.

For research use only. We do not sell to patients.

Vernolide B Chemical Structure

CAS No. : 618860-58-5

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Description

Vernolide-B has cytoxicity (ED₅₀s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	12.8 μM Compound: 7	Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay	[PMID: 22850207]
MCF7	IC₅₀	7.6 μM Compound: 10	Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay	[PMID: 26331426]
MDA-MB-231	IC₅₀	6.6 μM Compound: 10	Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay	[PMID: 26331426]
NIH3T3	IC₅₀	7.9 μM Compound: 10	Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells	[PMID: 26331426]
RAW264.7	IC₅₀	1.2 μM Compound: 7	Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method	[PMID: 22850207]
SF-295	IC₅₀	8.2 μM Compound: 10	Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay	[PMID: 26331426]
U-251	IC₅₀	3.2 μM Compound: 10	Inhibition of Stat3 dimer DNA binding activity in human U251MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE Inhibition of Stat3 dimer DNA binding activity in human U251MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE	[PMID: 26331426]
U-251	IC₅₀	3.4 μM Compound: 10	Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay	[PMID: 26331426]
U-373MG ATCC	IC₅₀	4.1 μM Compound: 10	Inhibition of Stat3 dimer DNA binding activity in human U373MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE Inhibition of Stat3 dimer DNA binding activity in human U373MG cells nuclear extract after 1.5 hrs by EMSA using radiolabeled probe hSIE	[PMID: 26331426]
U-373MG ATCC	IC₅₀	6.6 μM Compound: 10	Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay	[PMID: 26331426]

Molecular Weight

434.48

Formula

C₂₃H₃₀O₈

CAS No.

618860-58-5

SMILES

O=C(/C(C)=C/C)O[C@@H](C[C@H]1C)C(/C(OC2=O)=C\[C@](O[C@]13OC)(CC3)C)=C2COC(C)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kuo YH, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull (Tokyo). 2003 Apr;51(4):425-6. [Content Brief]

Vernolide B Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vernolide B618860-58-5OthersSesquiterpene lactoneanticancercytoxicityInhibitorinhibitorinhibit

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Vernolide B

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