2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. Verosudil hydrochloride

Verosudil hydrochloride  (Synonyms: AR-12286 hydrochloride)

Cat. No.: HY-16758A
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Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is an inhibitor for Rho-kinase (ROCK) with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork.

For research use only. We do not sell to patients.

Verosudil hydrochloride Chemical Structure

Verosudil hydrochloride Chemical Structure

CAS No. : 1414854-44-6

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Other Forms of Verosudil hydrochloride:

Verosudil hydrochloride Related Antibodies

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ROCK ROCK1 ROCK2

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Description

Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is an inhibitor for Rho-kinase (ROCK) with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

IC50 & Target

ROCK1

2 nM (Ki)

ROCK2

2 nM (Ki)

Molecular Weight

363.86

Formula

C17H18ClN3O2S
CAS No.
SMILES

O=C(C(C1=CSC=C1)N(C)C)NC2=CC3=C(C=C2)C(NC=C3)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Verosudil hydrochloride Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Verosudil1414854-44-6AR-12286AR12286AR 12286ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKselectiveaqueoushumourintraocularpressureIOPglaucomaInhibitorinhibitorinhibit

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