2. Cell Cycle/DNA Damage PROTAC
  3. DNA Alkylator/Crosslinker E3 Ligase Ligand-Linker Conjugates
  4. VH032 amide-PEG1-acid

VH032 amide-PEG1-acid (linker 10) is a VHL-1 alkyl linker that can be used to bind CDK4/6 ligands (PI) and degradation/destruction tags (EL) (e.g.,E3 ligase ligands).

For research use only. We do not sell to patients.

VH032 amide-PEG1-acid Chemical Structure

VH032 amide-PEG1-acid Chemical Structure

CAS No. : 2172820-07-2

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VH032 amide-PEG1-acid Related Antibodies

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Description

VH032 amide-PEG1-acid (linker 10) is a VHL-1 alkyl linker that can be used to bind CDK4/6 ligands (PI) and degradation/destruction tags (EL) (e.g.,E3 ligase ligands)[1].

Molecular Weight

574.69

Formula

C28H38N4O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCOCCC(O)=O)=O)=O)C[C@H](O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (217.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7401 mL 8.7003 mL 17.4007 mL
5 mM 0.3480 mL 1.7401 mL 3.4801 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7401 mL 8.7003 mL 17.4007 mL 43.5017 mL
5 mM 0.3480 mL 1.7401 mL 3.4801 mL 8.7003 mL
10 mM 0.1740 mL 0.8700 mL 1.7401 mL 4.3502 mL
15 mM 0.1160 mL 0.5800 mL 1.1600 mL 2.9001 mL
20 mM 0.0870 mL 0.4350 mL 0.8700 mL 2.1751 mL
25 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7401 mL
30 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4501 mL
40 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0875 mL
50 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
60 mM 0.0290 mL 0.1450 mL 0.2900 mL 0.7250 mL
80 mM 0.0218 mL 0.1088 mL 0.2175 mL 0.5438 mL
100 mM 0.0174 mL 0.0870 mL 0.1740 mL 0.4350 mL
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VH032 amide-PEG1-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH032 amide-PEG1-acid2172820-07-2DNA Alkylator/CrosslinkerE3 Ligase Ligand-Linker ConjugatesE3 ligase ligandCDK4/6 ligandInhibitorinhibitorinhibit

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