1. Cell Cycle/DNA Damage Cytoskeleton Autophagy
  2. Microtubule/Tubulin Autophagy
  3. Vinorelbine

Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Vinorelbine ditartrate) that retains the same biological activity.

For research use only. We do not sell to patients.

Vinorelbine Chemical Structure

Vinorelbine Chemical Structure

CAS No. : 71486-22-1

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Description

Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
60 nM
Compound: Vinorelbine
Antiproliferative activity against human A431 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A431 cells after 72 hrs by sulforhodamine B assay
[PMID: 21480626]
A549 IC50
0.03 μM
Compound: 1e
Cytotoxicity against human A549 cells by sulforhodamine B assay
Cytotoxicity against human A549 cells by sulforhodamine B assay
[PMID: 19499938]
A549 IC50
0.049 μM
Compound: 1e, AVLB
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 17544278]
A549 IC50
0.6 μM
Compound: Vinorelbine
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
A549 IC50
10 nM
Compound: 1d
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
[PMID: 22525316]
A549 IC50
26.1 μM
Compound: vinorelbine
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 20462230]
A549 IC50
36.9 nM
Compound: 1a
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 18771244]
A549 IC50
64.6 nM
Compound: Vinorelbine
Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
[PMID: 21480626]
A549 IC50
9 nM
Compound: 1d, NVB
Cytotoxicity against human A549 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 to 72 hrs by MTT assay
[PMID: 23107481]
HCC1937 IC50
> 10 μM
Compound: Vinorelbine
Antiproliferative activity against exponentially growing adherent human HCC1937 cells assessed as inhibition of cell proliferation after 72 hrs by luminescence detection based ATPlite assay
Antiproliferative activity against exponentially growing adherent human HCC1937 cells assessed as inhibition of cell proliferation after 72 hrs by luminescence detection based ATPlite assay
[PMID: 25872984]
HCT-116 IC50
0.0149 μM
Compound: Vinorelbine
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32473523]
HCT-116 IC50
0.015 μM
Compound: Vinorelbine
Cytotoxicity against human HCT116 cells after 72 hrs by resazurin-based fluorimetric assay
Cytotoxicity against human HCT116 cells after 72 hrs by resazurin-based fluorimetric assay
[PMID: 24901800]
HCT-116 IC50
15 nM
Compound: 3, VLN
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 72 hrs
[PMID: 25804719]
HCT-116 IC50
35 nM
Compound: 7, VLN
Cytotoxicity against human HCT116 cells after 72 hrs by resazurin assay
Cytotoxicity against human HCT116 cells after 72 hrs by resazurin assay
[PMID: 23822556]
HCT-116 IC50
35 nM
Compound: 4, VLN
Antiproliferative activity against human HCT116 cells after 72 hrs
Antiproliferative activity against human HCT116 cells after 72 hrs
[PMID: 24871162]
HCT-116 IC50
75 nM
Compound: 22
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by phosphatase assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by phosphatase assay
[PMID: 23252481]
HCT-116/VM46 IC50
600 nM
Compound: 22
Cytotoxicity against human vinblastine-resistant HCT116/VM46 cells assessed as growth inhibition after 72 hrs by phosphatase assay
Cytotoxicity against human vinblastine-resistant HCT116/VM46 cells assessed as growth inhibition after 72 hrs by phosphatase assay
[PMID: 23252481]
HeLa IC50
0.026 μM
Compound: 1e, AVLB
Cytotoxicity against human HeLa cells after 72 hrs by SRB assay
Cytotoxicity against human HeLa cells after 72 hrs by SRB assay
[PMID: 17544278]
HeLa IC50
0.027 μM
Compound: 1e
Cytotoxicity against human HeLa cells by sulforhodamine B assay
Cytotoxicity against human HeLa cells by sulforhodamine B assay
[PMID: 19499938]
HeLa IC50
0.066 μM
Compound: Vinorelbine
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
[PMID: 29624387]
HeLa IC50
26.9 nM
Compound: 1a
Cytotoxicity against human HeLa cells after 72 hrs by SRB assay
Cytotoxicity against human HeLa cells after 72 hrs by SRB assay
[PMID: 18771244]
HeLa IC50
27 nM
Compound: 1f, AVBL
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 22115594]
HeLa IC50
9 nM
Compound: 1d
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 22525316]
HepG2 IC50
0.11 μM
Compound: Vinorelbine
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32473523]
HepG2 IC50
23.12 μM
Compound: Vinorelbine
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 26420067]
HL-60 IC50
< 0.06 μM
Compound: vinorelbine
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 20462230]
HL-60 IC50
11.47 μM
Compound: Vinorelbine
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 26420067]
HT-29 IC50
11.9 nM
Compound: Vinorelbine
Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay
[PMID: 21480626]
HUVEC IC50
2 nM
Compound: 7, VLN
Cytotoxicity against HUVEC after 72 hrs by resazurin assay
Cytotoxicity against HUVEC after 72 hrs by resazurin assay
[PMID: 23822556]
K562 IC50
0.003 μM
Compound: 3; VLN
Cytotoxicity against human K562 cells incubated for 72 hrs by CellTiter 96 aqueous one solution reagent based assay
Cytotoxicity against human K562 cells incubated for 72 hrs by CellTiter 96 aqueous one solution reagent based assay
[PMID: 27753480]
K562 IC50
0.006 μM
Compound: Vinorelbine
Cytotoxicity against human K562 cells after 72 hrs by resazurin-based fluorimetric assay
Cytotoxicity against human K562 cells after 72 hrs by resazurin-based fluorimetric assay
[PMID: 24901800]
K562 IC50
20 nM
Compound: 7, VLN
Cytotoxicity against human K562 cells after 72 hrs by resazurin assay
Cytotoxicity against human K562 cells after 72 hrs by resazurin assay
[PMID: 23822556]
K562 IC50
3.5 nM
Compound: 4, VLN
Antiproliferative activity against human K562 cells after 72 hrs
Antiproliferative activity against human K562 cells after 72 hrs
[PMID: 24871162]
K562 IC50
6 nM
Compound: 3, VLN
Cytotoxicity against human K562 cells assessed as inhibition of cell proliferation after 72 hrs
Cytotoxicity against human K562 cells assessed as inhibition of cell proliferation after 72 hrs
[PMID: 25804719]
K-562R IC50
0.41 μM
Compound: 3; VLN
Cytotoxicity against doxorubicin-resistant human K562R cells incubated for 72 hrs by CellTiter 96 aqueous one solution reagent based assay
Cytotoxicity against doxorubicin-resistant human K562R cells incubated for 72 hrs by CellTiter 96 aqueous one solution reagent based assay
[PMID: 27753480]
KB IC50
0.001 μM
Compound: 4, nor-AVLB
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 19072542]
KB IC50
0.04 μM
Compound: 3, AVLB
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 19072542]
KB EC50
6 nM
Compound: Vinorelbine
Cell cycle arrest in human KB cells assessed as accumulation of cells at G2/M phase after 24 hrs by propidium iodide-based FACScan
Cell cycle arrest in human KB cells assessed as accumulation of cells at G2/M phase after 24 hrs by propidium iodide-based FACScan
[PMID: 21480626]
L1210 IC50
65 nM
Compound: 22
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 72 hrs by phosphatase assay
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 72 hrs by phosphatase assay
[PMID: 23252481]
MCF7 IC50
0.07 μM
Compound: vinorelbine
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 19743863]
MCF7 IC50
17.2 μM
Compound: vinorelbine
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 20462230]
MCF7 IC50
4 nM
Compound: 4, VLN
Antiproliferative activity against human MCF7 cells after 72 hrs
Antiproliferative activity against human MCF7 cells after 72 hrs
[PMID: 24871162]
MES-SA IC50
0.21 μM
Compound: Vinorelbine
Cytotoxicity against human MES-SA cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human MES-SA cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
MES-SA/Dx5 IC50
> 32 μM
Compound: Vinorelbine
Cytotoxicity against human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human MES-SA/Dx5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
NCI/ADR-RES IC50
5000 nM
Compound: VRB
Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against Pgp overexpressing human NCI-ADR-RES cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26132075]
NCI/ADR-RES IC50
5000 nM
Compound: VRB
Growth inhibition of human NCI/ADR-RES cells after 96 hrs by trypan blue exclusion assay
Growth inhibition of human NCI/ADR-RES cells after 96 hrs by trypan blue exclusion assay
[PMID: 29730191]
NCI/ADR-RES IC50
5000 nM
Compound: VRB
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay
[PMID: 23214452]
NCI/ADR-RES IC50
5000 nM
Compound: VRB
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
[PMID: 25025991]
NCI/ADR-RES IC50
5000 nM
Compound: VRB
Growth inhibition of doxorubicin-resistant human NCI-ADR-RES cells overexpressing P-glycoprotein after 96 hrs
Growth inhibition of doxorubicin-resistant human NCI-ADR-RES cells overexpressing P-glycoprotein after 96 hrs
[PMID: 22044164]
NCI-H1299 IC50
0.23 μM
Compound: Vinorelbine
Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
NCI-H1975 IC50
0.008 μM
Compound: Vinorelbine
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32473523]
NCI-H460 IC50
43.7 nM
Compound: Vinorelbine
Antiproliferative activity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay
[PMID: 21480626]
NCI-H661 IC50
0.12 μM
Compound: Vinorelbine
Cytotoxicity against human NCI-H661 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human NCI-H661 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
[PMID: 33588178]
OVCAR-8 IC50
300 nM
Compound: VRB
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 26132075]
OVCAR-8 IC50
300 nM
Compound: VRB
Growth inhibition of human OVCAR8 cells after 96 hrs by trypan blue exclusion assay
Growth inhibition of human OVCAR8 cells after 96 hrs by trypan blue exclusion assay
[PMID: 29730191]
OVCAR-8 IC50
300 nM
Compound: VRB
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition by trypan blue exclusion assay
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition by trypan blue exclusion assay
[PMID: 23214452]
OVCAR-8 IC50
300 nM
Compound: VRB
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy
[PMID: 25025991]
OVCAR-8 IC50
300 nM
Compound: VRB
Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs
Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs
[PMID: 22044164]
SK-OV-3 IC50
26.7 nM
Compound: Vinorelbine
Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
[PMID: 21480626]
SMMC-7721 IC50
4.7 μM
Compound: vinorelbine
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
[PMID: 20462230]
SW480 IC50
> 40 μM
Compound: vinorelbine
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
[PMID: 20462230]
U-87MG ATCC IC50
2 nM
Compound: 7, VLN
Cytotoxicity against human U87MG cells after 72 hrs by resazurin assay
Cytotoxicity against human U87MG cells after 72 hrs by resazurin assay
[PMID: 23822556]
U-87MG ATCC IC50
2 nM
Compound: 4, VLN
Antiproliferative activity against human U87 cells after 72 hrs
Antiproliferative activity against human U87 cells after 72 hrs
[PMID: 24871162]
U-87MG ATCC IC50
3.5 nM
Compound: 3, VLN
Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 72 hrs
Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 72 hrs
[PMID: 25804719]
In Vitro

Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

778.93

Formula

C45H54N4O8

CAS No.
SMILES

CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C(C=C([C@](C4=C5C(C=CC=C6)=C6N4)(C[C@@](C=C(CC)C7)([H])C[N@]7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Vinorelbine
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