2. Anti-infection
  3. Fungal
  4. Voriconazole-d3

Voriconazole-d3  (Synonyms: UK-109496-d3)

Cat. No.: HY-76200S Purity: 99.56%
COA Handling Instructions

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Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

For research use only. We do not sell to patients.

Voriconazole-d<sub>3</sub> Chemical Structure

Voriconazole-d3 Chemical Structure

CAS No. : 1217661-14-7

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1 mg USD 310 In-stock
5 mg USD 713 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Voriconazole-d3:

Voriconazole-d3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Voriconazole-d3 Related Antibodies
Molecular Weight

352.33

Formula

C16H11D3F3N5O
CAS No.
Unlabeled CAS

137234-62-9
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])[C@@H](C1=NC=NC=C1F)[C@@](O)(C2=C(C=C(C=C2)F)F)CN3C=NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (141.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 50 mg/mL (141.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.17 mg/mL (0.48 mM; Need ultrasonic)

H2O : 0.17 mg/mL (0.48 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8382 mL 14.1912 mL 28.3825 mL
5 mM 0.5676 mL 2.8382 mL 5.6765 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.8382 mL 14.1912 mL 28.3825 mL 70.9562 mL
5 mM 0.5676 mL 2.8382 mL 5.6765 mL 14.1912 mL
10 mM 0.2838 mL 1.4191 mL 2.8382 mL 7.0956 mL
15 mM 0.1892 mL 0.9461 mL 1.8922 mL 4.7304 mL
20 mM 0.1419 mL 0.7096 mL 1.4191 mL 3.5478 mL
25 mM 0.1135 mL 0.5676 mL 1.1353 mL 2.8382 mL
30 mM 0.0946 mL 0.4730 mL 0.9461 mL 2.3652 mL
40 mM 0.0710 mL 0.3548 mL 0.7096 mL 1.7739 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4191 mL
60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1826 mL
80 mM 0.0355 mL 0.1774 mL 0.3548 mL 0.8870 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7096 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Voriconazole-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Voriconazole-d31217661-14-7UK-109496-d3FungalInhibitorinhibitorinhibit

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