Vormatrigine

Cat. No.: HY-159819 Purity: 99.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Vormatrigine is an orally active sodium channel inhibitor with anti-epileptic activity. Vormatrigine has a specific inhibitory effect on overactive NaV channels in vitro and has a good inhibitory effect in the maximal electroconvulsive seizure (MES) model. Vormatrigine can be used to study human focal and generalized epilepsy.

For research use only. We do not sell to patients.

Vormatrigine Chemical Structure

CAS No. : 2392951-18-5

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5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability
100 mg		Check price and availability

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Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

406.28

Formula

C₁₆H₁₂F₆N₄O₂

CAS No.

2392951-18-5

Appearance

Solid

Color

White to off-white

SMILES

FC1=C(OCC(F)(F)F)N=CC(C2=CN3C(C(F)(OCC)F)=NN=C3C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (430.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4614 mL	12.3068 mL	24.6136 mL
5 mM	0.4923 mL	2.4614 mL	4.9227 mL
10 mM	0.2461 mL	1.2307 mL	2.4614 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (247 KB) HNMR (260 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Praxis Precision Medicines, Inc. Preparation of pyridin-3-yl substituted triazolopyrazines, triazolopyridazines, and triazolopyridines as ion channel modulators. World Intellectual Property Organization, WO2019232209 A1 2019-12-05

[2]. Praxis Presentation of Epilepsy Program Advances Set for 2024 American Epilepsy Society Annual Meeting

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4614 mL	12.3068 mL	24.6136 mL	61.5339 mL
	5 mM	0.4923 mL	2.4614 mL	4.9227 mL	12.3068 mL
	10 mM	0.2461 mL	1.2307 mL	2.4614 mL	6.1534 mL
	15 mM	0.1641 mL	0.8205 mL	1.6409 mL	4.1023 mL
	20 mM	0.1231 mL	0.6153 mL	1.2307 mL	3.0767 mL
	25 mM	0.0985 mL	0.4923 mL	0.9845 mL	2.4614 mL
	30 mM	0.0820 mL	0.4102 mL	0.8205 mL	2.0511 mL
	40 mM	0.0615 mL	0.3077 mL	0.6153 mL	1.5383 mL
	50 mM	0.0492 mL	0.2461 mL	0.4923 mL	1.2307 mL
	60 mM	0.0410 mL	0.2051 mL	0.4102 mL	1.0256 mL
	80 mM	0.0308 mL	0.1538 mL	0.3077 mL	0.7692 mL
	100 mM	0.0246 mL	0.1231 mL	0.2461 mL	0.6153 mL

Vormatrigine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vormatrigine2392951-18-5Sodium ChannelNa channelsNa+ channelsSodium channelinhibitorMES modelanti-epilepticInhibitorinhibit

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